Association of Single Nucleotide Polymorphism rs11172113 of LRP1 Gene with Migraine in South Indian Population – A Study

Abstract

Migraine is a weakening neurological disorder with a polygenic inheritance caused by multiple factors – both environmental and genetic. The variegated ethnicity of India makes it a fertile field for research into genetic of migraine. Approaches to migraine therapy based on its mechanism of action has led scholars to associate Single nucleotide polymorphisms (SNPs) of various genes with migraine to improve the understanding of genetics of
classical and common migraine. One such SNP is rs11172113 of the LRP1 gene which is localized for common migraine. The association of this SNP in South Indian origin is considered in this study. The results of this study indicated that migraine is more prevalent among female population and female migraineurs exhibited CT polymorphism to greater extent. This association could be attributed to the involvement of LRP1 locus and the
NMDA glutamate receptor co-localization. A mutation in this locus might lead to increased glutamate levels which cause excititoxicity, thereby leading to neurodegeneration and neuronal damage and this might be the cause of headache in migraine.