Genetics Behind Uterine Fibroids

Abstract

Uterine Fibroids is a condition of women specific benign tumor, the clonal neoplasms of smooth muscles with fibroblasts in the uterus. In India uterine fibroids constitute about 37% in rural and 24% in urban population.  These fibroids if untreated may become the cause for gynecological disturbances and in some cases fertility issues. Fibroids occur mainly due to the hormonal imbalances in the women during the age of fertility. Apart from its hereditary issues fibroids are regulated by plethora of genes and gene clusters making them a subject of genetic research. The objective of the current review is to identify and study all the genes playing a pivotal role in the development of uterine fibroids. This can be achieved by a crucial data mining protocol along with a focus on mining the gene data bases like NCBI, Gene Cards etc,. Once the list of genes is produced it can be a crucial resource for the genetic annotation of the condition and therapeutic analysis.