Proteomic analysis and Identification of potential peptide Vaccine against pathogenic proteins of Pseudomonas

Abstract

Pseudomonas is a gram negative facultative anaerobic bacterium with ubiquitous occurrence. It is one of the common pathogens infecting humans and animals. It would cause acute to chronic infections and forms an opportunistic parasite for immune suppressed individuals. Some of the most common infections include malignant external otitis, pneumonia, septicemia etc. In alignment with its role in threatening of human and animal health the study aimed to annotate the complete proteome of the organism for identification of pathogenic protein cluster among them. Further based on the identified proteins the suitable peptide vaccines are to be designed which can prevent the atrocities caused by this bacterium. The 3D structure of proposed peptide vaccine can further be designed using ARGUS LAB followed by it validation. The planned work could screen and identify major pathogenic peptides from the bacterium which can be designed and validated. The use of these designed peptides as vaccines can be one of  the preventive approaches for all infections caused by this opportunistic pathogen.